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1: Bioorg Med Chem Lett. 2008 Feb 15;18(4):1308-11. Epub 2008 Jan 11.Click here to read Links

Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents.

Zhou C, Min J, Liu Z, Young A, Deshazer H, Gao T, Chang YT, Kallenbach NR.

Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.

Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.

PMID: 18226902 [PubMed - indexed for MEDLINE]