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J Card Fail. 2008 Feb;14(1):61-74. doi: 10.1016/j.cardfail.2007.09.006.

Cytokines and myocardial dysfunction: state of the art.

Author information

  • Weill Cornell Faculty of Medicine, Doha, Qatar.

Abstract

BACKGROUND:

Myocardial dysfunction has been associated with inflammation and cytokine modulation.

OBJECTIVES:

The study objective was to understand the role of cytokines in the pathophysiology and management of myocardial dysfunction.

METHODS:

Heart failure has been revisited with revision of the pertinent published articles in the Medline, Scopus, Cochrane Database of Systematic Reviews, and EBSCO Host research.

RESULTS:

For the proinflammatory cytokines, illumination of this important point requires further diagnostic and therapeutic investigations. Data on chronic heart failure are not so reassuring; therefore, patients with advanced heart failure should not be treated with anticytokines at this time.

CONCLUSION:

Further studies are warranted to pave the way for introducing cytokine and immunomodulation therapy at the optimal and appropriate time.

PMID:
18226775
[PubMed - indexed for MEDLINE]
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