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Curr Opin Cell Biol. 2008 Feb;20(1):71-6. doi: 10.1016/j.ceb.2007.11.010. Epub 2008 Jan 15.

Tubulin modifications and their cellular functions.

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  • 1Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Abstract

All microtubules are built from a basic alpha/beta-tubulin building block, yet subpopulations of microtubules can be differentially marked by a number of post-translational modifications. These modifications, conserved throughout evolution, are thought to act individually or in combination to control specific microtubule-based functions, analogous to how histone modifications regulate chromatin functions. Here we review recent studies demonstrating that tubulin modifications influence microtubule-associated proteins such as severing proteins, plus-end tracking proteins, and molecular motors. In this way, tubulin modifications play an important role in regulating microtubule properties, such as stability and structure, as well as microtubule-based functions, such as ciliary beating, cell division, and intracellular trafficking.

PMID:
18226514
[PubMed - indexed for MEDLINE]
PMCID:
PMC2274889
Free PMC Article
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