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1: Biol Direct. 2008 Jan 28;3:3.Click here to read Click here to read Links

Predicting the conformations of peptides and proteins in early evolution. A review article submitted to Biology Direct.

Milner-White EJ, Russell MJ.

Institute of Biomedical and Life Sciences, University of Glasgow, G12 8QQ, UK. J.Milner-White@bio.gla.ac.uk

Considering that short, mainly heterochiral, polypeptides with a high glycine content are expected to have played a prominent role in evolution at the earliest stage of life before nucleic acids were available, we review recent knowledge about polypeptide three-dimensional structure to predict the types of conformations they would have adopted. The possible existence of such structures at this time leads to a consideration of their functional significance, and the consequences for the course of evolution.

PMID: 18226248 [PubMed - indexed for MEDLINE]

PMCID: PMC2241844