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Genome Biol. 2008 Jan 22;9(1):201. doi: 10.1186/gb-2008-9-1-201.

Anchoring the genome.

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  • 1Cancer Research UK London Research Institute, Lincoln's Inn Fields, London WC2A 3PX, UK.

Abstract

Although the principles governing chromosomal architecture are largely unresolved, there is evidence that higher-order chromatin folding is mediated by the anchoring of specific DNA sequences to the nuclear matrix. These genome anchors are also crucial regulators of gene expression and DNA replication, and play a role in pathogenesis.

PMID:
18226181
[PubMed - indexed for MEDLINE]
PMCID:
PMC2395230
Free PMC Article
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