Tuberk Toraks. 2007;55(4):400-3.

Late fatal recurrence in gefitinib-treated NSCLC patients.

Miyazaki K, Ano T, Nakazawa K, Satoh H, Ohtsuka M.

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Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Japan.

Abstract

Gefitinib is a selective epidermal growth factor receptor tyrosine kinase inhibitor, which blocks signal transduction pathways implicated in proliferation and survival of cancer cells. Long-term survival in patients with metastatic non-small-cell lung carcinoma (NSCLC) treated with gefitinib has recently been reported. We showed herein two cases of fatal rapid recurrence after a long-term disease control by gefitinib. The biology of fatal aggressive recurrence of gefitinib-treated NSCLC is not well characterized. Regardless of the mechanism, however, physicians treating patients with gefitinib should be alert to the possibility of fatal rapid recurrence after a long-term disease control by this drug.

PMID:: 18224510; [PubMed - indexed for MEDLINE]

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Late fatal recurrence in gefitinib-treated NSCLC patients.

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