Nat Biotechnol. 2008 Feb;26(2):212-4. Epub 2008 Jan 27.

Human embryonic stem cell derivation from poor-quality embryos.

Lerou PH, Yabuuchi A, Huo H, Takeuchi A, Shea J, Cimini T, Ince TA, Ginsburg E, Racowsky C, Daley GQ.

Source

Division of Newborn Medicine, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.

Abstract

During in vitro fertilization, embryos deemed clinically useless based on poor morphology are typically discarded. Here we demonstrate a statistical correlation between the developmental stage of such poor-quality embryos and the yield of human embryonic stem (hES) cell lines. Early-arrested or highly fragmented embryos only rarely yield cell lines, whereas those that have achieved blastocyst stage are a robust source of normal hES cells.

PMID:: 18223642; [PubMed - indexed for MEDLINE]

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