J Inorg Biochem. 2008 May-Jun;102(5-6):1159-69. Epub 2007 Dec 14.

Metal trafficking via siderophores in Gram-negative bacteria: specificities and characteristics of the pyoverdine pathway.

Source

Université Strasbourg 1, Institut Gilbert Laustriat, CNRS - UMR 7175, ESBS, 67412 Illkirch Cedex, France. schalk@esbs.u-strasbg.fr

Abstract

Under iron-limiting conditions, fluorescent pseudomonads secrete fluorescent siderophores called pyoverdines (Pvd), which form complexes with iron that are then taken up by the bacteria. Pvds consist of a fluorescent chromophore derived from 2,3-diamino-6,7-dihydroxyquinoline and containing one of the bidentate groups involved in iron chelation, linked to a peptide moiety containing the other two bidentate groups required for binding to Fe3+. More than 100 different Pvds have been identified, with different peptide sequences, forming a wide family of siderophores. In the human opportunistic pathogen Pseudomonas aeruginosa, Pvd is necessary for infection and is considered to be a virulence factor. This review focuses on the mechanisms underlying iron uptake by the Pvd pathway in pseudomonads, taking into account recent biochemical and biophysical studies and recently solved 3D-structures of the Pvd outer membrane transporter FpvA in four different loading states. These data are discussed and compared with the mechanisms of siderophore-Fe uptake reported for other Gram-negative bacteria.

PMID:: 18221784; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

IRON - HSDB

Supplemental Content

Save items

Related citations in PubMed

FpvA bound to non-cognate pyoverdines: molecular basis of siderophore recognition by an iron transporter. [Mol Microbiol. 2009]
FpvA bound to non-cognate pyoverdines: molecular basis of siderophore recognition by an iron transporter.
Greenwald J, Nader M, Celia H, Gruffaz C, Geoffroy V, Meyer JM, Schalk IJ, Pattus F. Mol Microbiol. 2009 Jun; 72(5):1246-59.
The structure-activity relationship of ferric pyoverdine bound to its outer membrane transporter: implications for the mechanism of iron uptake. [Biochemistry. 2005]
The structure-activity relationship of ferric pyoverdine bound to its outer membrane transporter: implications for the mechanism of iron uptake.
Schons V, Atkinson RA, Dugave C, Graff R, Mislin GL, Rochet L, Hennard C, Kieffer B, Abdallah MA, Schalk IJ. Biochemistry. 2005 Nov 1; 44(43):14069-79.
Identification of residues of FpvA involved in the different steps of Pvd-Fe uptake in Pseudomonas aeruginosa. [Biochemistry. 2007]
Identification of residues of FpvA involved in the different steps of Pvd-Fe uptake in Pseudomonas aeruginosa.
Nader M, Dobbelaere W, Vincent M, Journet L, Adams H, Cobessi D, Gallay J, Schalk IJ. Biochemistry. 2007 Oct 23; 46(42):11707-17. Epub 2007 Sep 27.
Review A new mechanism for membrane iron transport in Pseudomonas aeruginosa. [Biochem Soc Trans. 2002]
Review A new mechanism for membrane iron transport in Pseudomonas aeruginosa.
Schalk IJ, Abdallah MA, Pattus F. Biochem Soc Trans. 2002 Aug; 30(4):702-5.
Review Diversity of siderophore-mediated iron uptake systems in fluorescent pseudomonads: not only pyoverdines. [Environ Microbiol. 2002]
Review Diversity of siderophore-mediated iron uptake systems in fluorescent pseudomonads: not only pyoverdines.
Cornelis P, Matthijs S. Environ Microbiol. 2002 Dec; 4(12):787-98.

See reviews... See all...

Cited by 7 PubMed Central articles

Phenazine-1-carboxylic acid promotes bacterial biofilm development via ferrous iron acquisition. [J Bacteriol. 2011]
Phenazine-1-carboxylic acid promotes bacterial biofilm development via ferrous iron acquisition.
Wang Y, Wilks JC, Danhorn T, Ramos I, Croal L, Newman DK. J Bacteriol. 2011 Jul; 193(14):3606-17. Epub 2011 May 20.
Niobium uptake and release by bacterial ferric ion binding protein. [Bioinorg Chem Appl. 2010]
Niobium uptake and release by bacterial ferric ion binding protein.
Shi Y, Harvey I, Campopiano D, Sadler PJ. Bioinorg Chem Appl. 2010; :307578. Epub 2010 Apr 28.
Identification of a siderophore utilization locus in nontypeable Haemophilus influenzae. [BMC Microbiol. 2010]
Identification of a siderophore utilization locus in nontypeable Haemophilus influenzae.
Morton DJ, Turman EJ, Hensley PD, VanWagoner TM, Seale TW, Whitby PW, Stull TL. BMC Microbiol. 2010 Apr 15; 10:113. Epub 2010 Apr 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Metal trafficking via siderophores in Gram-negative bacteria: specificities and ...
Metal trafficking via siderophores in Gram-negative bacteria: specificities and characteristics of the pyoverdine pathway.
J Inorg Biochem. 2008 May-Jun ;102(5-6):1159-69. Epub 2007 Dec 14 .

PubMed
The role of glutamate in mood disorders: results from the ketamine in major depr...
The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects.
Curr Psychiatry Rep. 2007 Dec ;9(6):467-74.

PubMed
Treatment options in acute porphyria, porphyria cutanea tarda, and erythropoieti...
Treatment options in acute porphyria, porphyria cutanea tarda, and erythropoietic protoporphyria.
Curr Treat Options Gastroenterol. 2007 Dec ;10(6):444-55.

PubMed
A hidden HIV epidemic among women in Vietnam.
A hidden HIV epidemic among women in Vietnam.
BMC Public Health. 2008 Jan 28 ;8:37.

PubMed
Improving physical quality of life with group physical activity in the adjunctiv...
Improving physical quality of life with group physical activity in the adjunctive treatment of major depressive disorder.
Clin Pract Epidemiol Ment Health. 2008 Jan 26 ;4:1.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: