Send to:

Choose Destination
See comment in PubMed Commons below
Pediatr Diabetes. 2008 Jun;9(3 Pt 2):57-61. doi: 10.1111/j.1399-5448.2007.00350.x. Epub 2008 Jan 21.

Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescents.

Author information

  • 1Division of Pediatric Endocrinology, Department of Pediatrics, The Clinical Research Center, The Ohio State University College of Medicine and Public Health, Columbus, OH, USA.


Insulin stimulates muscle glucose uptake and inhibits hepatic glucose production. Measures of insulin sensitivity or insulin resistance must take both of these actions into account. Homeostatic model assessment of insulin resistance (HOMA(IR)) and quantitative insulin sensitivity check index (QUICKI) are two simple measures of insulin resistance and insulin sensitivity that are derived from fasting glucose and insulin levels as such it is likely that they reflect primary hepatic insulin action and not muscular effects. To prove this hypothesis, the relationships of HOMA(IR) and QUICKI to peripheral insulin sensitivity (S(I)(*)) and hepatic insulin resistance (HIR) were assessed in 34 adolescents (age 13.5 +/- 2.9 yr, body mass index 23.0 +/- 5.7, mean +/- SD; 16 Caucasian and 14 African-American). S(I)(*) and HIR were determined using the stable-labeled, frequently sampled intravenous glucose tolerance test (250 mg total glucose/kg, 13% [6,6]-D(2)-glucose). The former was calculated using the one-compartment minimal model and stable glucose concentration (S(I)(*)), and the latter was determined over the last hour of the study by multiplying hepatic glucose production (Steele's equation) by mean plasma insulin concentration. As expected, HOMA(IR) and QUICKI were significantly related to HIR (log HOMA(IR) and log HIR, r = 0.73, p < 0.001; QUICKI and log HIR, r = -0.69, p < 0.001) but not S(I)(*). When both S(I)(*) and HIR were included in the equations, only the relationships to log HIR were significant (log HOMA(IR), p < 0.001; QUICKI, p < 0.001). The relationships were similar in African-American and Caucasian subjects. These results demonstrate that in adolescents, HOMA(IR) and QUICKI assess hepatic but not peripheral insulin action.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk