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J Dtsch Dermatol Ges. 2008 Apr;6(4):273-9. doi: 10.1111/j.1610-0387.2008.06493.x. Epub 2008 Jan 21.

The aging male--diagnosis and therapy of late-onset hypogonadism.

[Article in English, German]

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  • 1Department of Dermatology and Allergology, University Clinic of Jena, Friedrich Schiller University, Jena, Germany.


Managing the clinical features of hormone insufficiency in aging men is an important field of activity for dermatologists and in particular for dermatologists specialized in andrology. Potential consequences of age-associated decrease in plasma testosterone levels include long-term changes in diverse organ systems including changes of bone architecture, body composition, muscular strength, cognitive functions, and mood as well as negative effects on skin and hair. Indications and contraindications for a hormone replacement therapy as well as therapy monitoring are well-defined. Replacement of testosterone in the case of late-onset hypogonadism is not a standardized therapy. Previous studies suggest that testosterone replacement therapy has positive clinical effects. Dermatologic effects of testosterone replacement therapy have not yet been investigated. Further research is required to identify potential benefits and risks of hormone replacement therapy in aging men.

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