Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mol Pharm. 2008 Mar-Apr;5(2):191-211. doi: 10.1021/mp700137g. Epub 2008 Jan 25.

Nonribosomal peptide synthetases involved in the production of medically relevant natural products.

Author information

  • 1Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Abstract

Natural products biosynthesized wholly or in part by nonribosomal peptide synthetases (NRPSs) are some of the most important drugs currently used clinically for the treatment of a variety of diseases. Since the initial research into NRPSs in the early 1960s, we have gained considerable insights into the mechanism by which these enzymes assemble these natural products. This review will present a brief history of how the basic mechanistic steps of NRPSs were initially deciphered and how this information has led us to understand how nature modified these systems to generate the enormous structural diversity seen in nonribosomal peptides. This review will also briefly discuss how drug development and discovery are being influenced by what we have learned from nature about nonribosomal peptide biosynthesis.

PMID:
18217713
[PubMed - indexed for MEDLINE]
PMCID:
PMC3131160
Free PMC Article

Images from this publication.See all images (11)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for American Chemical Society Icon for PubMed Central
    Loading ...
    Write to the Help Desk