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Pimecrolimus 1% cream in the treatment of facial psoriasis: a 16-week open-label study.
Department of Dermatology, University Hospital Marburg, Marburg, Germany. Arnd.Jacobi@med.uni-marburg.de
BACKGROUND: Facial psoriasis requires a treatment approach other than topical corticosteroids which bear the risk of skin atrophy. Topical pimecrolimus has been shown to be effective in atopic eczema and recently in psoriasis. OBJECTIVE: The aim of this open-label single-center investigator-initiated study was to evaluate the efficacy and safety of pimecrolimus 1% cream in patients with facial psoriasis. METHODS: 20 adults with facial psoriasis were enrolled. Pimecrolimus 1% cream was applied twice daily to psoriatic lesions of the face over an 8-week period. An 8-week follow-up was added. RESULTS: All clinical parameters showed a significant improvement after 8 and 16 weeks compared to baseline. Pimecrolimus 1% cream was effective and well tolerated. CONCLUSIONS: This is the first clinical study with a larger patient cohort reporting a relevant therapeutic effect and favorable safety profile of pimecrolimus 1% cream in facial psoriasis. (c) 2008 S. Karger AG, Basel.
PMID: 18216475 [PubMed - indexed for MEDLINE]
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Patient Drug Information
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Tacrolimus (Prograf® )
Tacrolimus is used along with other medications to prevent rejection (attack of a transplanted organ by the immune system of a person receiving the organ) in people who have received kidney, liver, or heart transplants. ...
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Tacrolimus Topical (Protopic® )
Tacrolimus ointment is used to treat the symptoms of eczema (atopic dermatitis; a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes) in patients who cannot use other medicat...
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Pimecrolimus Topical (Elidel® )
Pimecrolimus is used to control the symptoms of eczema (atopic dermatitis; a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Pimecrolimus is only used to treat patients ...