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N Engl J Med. 2008 Jan 24;358(4):369-74. doi: 10.1056/NEJMoa0707255.

Chimerism and tolerance in a recipient of a deceased-donor liver transplant.

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  • 1Centre for Kidney Research, Children's Hospital at Westmead and the Department of Paediatrics and Child Health, University of Sydney, Sydney, Australia.


Complete hematopoietic chimerism and tolerance of a liver allograft from a deceased male donor developed in a 9-year-old girl, with no evidence of graft-versus-host disease 17 months after transplantation. The tolerance was preceded by a period of severe hemolysis, reflecting partial chimerism that was refractory to standard therapies. The hemolysis resolved after the gradual withdrawal of all immunosuppressive therapy.

Copyright 2008 Massachusetts Medical Society.

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