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Biochem Soc Trans. 2008 Feb;36(Pt 1):72-7. doi: 10.1042/BST0360072.

AAA+ proteins: diversity in function, similarity in structure.

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  • 1Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, M5S 1A8.

Abstract

The AAA+ (ATPases associated with various cellular activities) superfamily of proteins represents a distinct lineage of the larger class of P-loop NTPases. Members of this superfamily use the power of nucleotide binding and hydrolysis to direct molecular remodelling events. All AAA+ proteins share a common core architecture, which, through various sequence and structural modifications, has been adapted for use in a remarkably diverse range of functions. The following mini-review provides a concise description of the major structural elements common to all AAA+ proteins in the context of their mechanistic roles. In addition, the evolutionary and functional diversity of this superfamily is described on the basis of recent classification studies.

PMID:
18208389
[PubMed - indexed for MEDLINE]
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