FEBS Lett. 2008 Feb 20;582(4):503-9. Epub 2008 Jan 17.

Transcript-specific translational regulation in the unfolded protein response of Saccharomyces cerevisiae.

Payne T, Hanfrey C, Bishop AL, Michael AJ, Avery SV, Archer DB.

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School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK.

Abstract

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes stress and induces the unfolded protein response (UPR). Genome-wide analysis of translational regulation in response to the UPR-inducing agent dithiothreitol in Saccharomyces cerevisiae is reported. Microarray analysis, confirmed using qRT-PCR, identified transcript-specific translational regulation. Transcripts with functions in ribosomal biogenesis and assembly were translationally repressed. In contrast, mRNAs from known UPR genes, encoding the UPR transcription factor Hac1p, the ER-oxidoreductase Ero1p and the ER-associated protein degradation (ERAD) protein Der1p, were enriched in polysomal fractions, indicating translational up-regulation. Splicing of HAC1 mRNA is shown to be required for efficient ribosomal loading.

PMID:: 18206654; [PubMed - indexed for MEDLINE]

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