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Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):667-8. doi: 10.1002/ajmg.b.30658.

Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.

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  • 1Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina 27710, USA.


It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory.

Copyright 2008 Wiley-Liss, Inc.

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