Nutr Clin Pract. 2008 Feb;23(1):42-8.

Inflammatory mediators and home parenteral nutrition.

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Department of Dietetics and Nutrition, University of Kansas Medical Center, 3901 Rainbow Boulevard 4096 DELP, Mail Stop 4013, Kansas City, KS 66160-7250, USA. mhise@kumc.edu

Abstract

Individuals who have sustained intestinal failure due to trauma or disease are able to survive through the use of parenteral nutrition (PN). Although home PN (HPN) is a lifesaving therapy, patients may, over the long term, be at risk for liver, bone, and immune dysfunction. A limited number of human studies and a large number of animal studies suggest that there may be a chronic inflammatory condition and additionally a potentially lower T-lymphocyte immune function associated with PN administration. This article will primarily focus on a review of the limited clinical literature that examines the effect of long-term PN on the occurrence of inflammatory mediators in HPN patients, and will discuss the factors that are currently hypothesized to contribute to the potential inflammatory sequelae.

PMID:: 18203963; [PubMed - indexed for MEDLINE]

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Review

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Inflammation Mediators

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