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Bioinformatics. 2008 Feb 15;24(4):458-61. doi: 10.1093/bioinformatics/btn007. Epub 2008 Jan 18.

BEN: a novel domain in chromatin factors and DNA viral proteins.

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  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.

Abstract

We report a previously uncharacterized alpha-helical module, the BEN domain, in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Contextual analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral proteins also suggests a possible role for them in organization of viral DNA during replication or transcription.

PMID:
18203771
[PubMed - indexed for MEDLINE]
PMCID:
PMC2477736
Free PMC Article

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