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Results Probl Cell Differ. 2008;46:181-99. doi: 10.1007/400_2007_053.

Biological function of prokineticins.

Author information

  • 1Department of Pharmacology, University of California, Irvine, CA 92697, USA. qzhou@uci.edu

Abstract

Secreted peptides have been implicated in diverse physiological functions. Prokineticins are a pair of regulatory peptides that signal through two highly homologous G protein-coupled receptors. Prokineticins possess a unique structural motif of five disulfide bonds and conserved N-terminal stretches. Diverse biological functions, ranging from development to adult physiology, have been attributed to prokineticins. Herein we provide an overview of current knowledge of this interesting pair of regulatory peptides.

PMID:
18202926
[PubMed - indexed for MEDLINE]
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