Cancer Cells. 1991 Dec;3(12):517-24.

JE/MCP-1: an early-response gene encodes a monocyte-specific cytokine.

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Division of Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

Abstract

The JE gene was one of the first growth-factor-inducible early-response genes to be identified. Sequence and expression analysis have revealed that JE encodes the monocyte-specific cytokine MCP-1 (also known as MCAF, TDCF, and SMC-CF). JE/MCP-1 specifically attracts monocytes in vitro and in vivo, but has no detectable effects on neutrophils or lymphocytes. In addition, JE/MCP-1 can suppress tumor formation in animal models by attracting and activating monocytes. These discoveries have drawn together the investigations of those who study the molecular basis of cell proliferation and those who work on the molecular basis of the inflammatory response.

PMID:: 1820095; [PubMed - indexed for MEDLINE]

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Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes. [Blood. 1991]
Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes.
Rollins BJ, Walz A, Baggiolini M. Blood. 1991 Aug 15; 78(4):1112-6.
Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. [Mol Cell Biol. 1991]
Suppression of tumor formation in vivo by expression of the JE gene in malignant cells.
Rollins BJ, Sunday ME. Mol Cell Biol. 1991 Jun; 11(6):3125-31.
Retinoic acid suppression of c-fos gene inhibits expression of tumor necrosis factor-alpha-induced monocyte chemoattractant JE/MCP-1 in clonal osteoblastic MC3T3-E1 cells. [J Biol Chem. 1994]
Retinoic acid suppression of c-fos gene inhibits expression of tumor necrosis factor-alpha-induced monocyte chemoattractant JE/MCP-1 in clonal osteoblastic MC3T3-E1 cells.
Hanazawa S, Takeshita A, Kitano S. J Biol Chem. 1994 Aug 19; 269(33):21379-84.
Review Human monocyte chemoattractant protein-1: structure and function. [Cytokines. 1992]
Review Human monocyte chemoattractant protein-1: structure and function.
Yoshimura T, Leonard EJ. Cytokines. 1992; 4:131-52.
Review Human monocyte chemoattractant protein-1 (MCP-1). [Immunol Today. 1990]
Review Human monocyte chemoattractant protein-1 (MCP-1).
Leonard EJ, Yoshimura T. Immunol Today. 1990 Mar; 11(3):97-101.

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