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Immunity. 2008 Jan;28(1):5-7. doi: 10.1016/j.immuni.2007.12.006.

Regulation of T helper 17 differentiation by orphan nuclear receptors: it's not just ROR gamma t anymore.

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  • 1Department of Pathology, Harvard Medical School, and Immune Disease Institute, Boston, MA 02115, USA.


T cells that produce IL-17 (T helper 17 cells) are implicated in autoimmune pathogenesis. In this issue of Immunity, Yang et al. (2008) report that the closely related orphan nuclear receptors ROR alpha and ROR gamma t work together to regulate T helper (Th)17 cell differentiation.

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