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Org Lett. 2008 Feb 21;10(4):557-60. doi: 10.1021/ol702500u. Epub 2008 Jan 17.

Direct electrophilic monofluoromethylation.

Author information

  • 1Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, USA. gprakash@usc.edu

Abstract

Monofluoromethyl derivatives of various nucleophiles have been synthesized using a new electrophilic monofluoromethylating reagent developed. The S-(monofluoromethyl)diarylsulfonium tetrafluoroborate has been shown to be effective for the introduction of an electrophilic monofluoromethyl group into C, S, O, N, and P nucleophiles. This methodology has been expanded for the synthesis of various biologically important compounds.

PMID:
18198880
[PubMed - indexed for MEDLINE]
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