Lipids. 1991 Dec;26(12):1277-9.

Role for platelet-activating factor in asthma.

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Department of Thoracic Medicine, National Heart & Lung Institute, London, United Kingdom.

Abstract

Recent studies of the effects of platelet-activating factor (PAF) on human and animal airways would support a putative role for this lipid mediator in asthma. PAF can induce many aspects of the clinical and pathological features seen in asthmatic airways such as airway oedema, eosinophil accumulation in the airway wall, and bronchial hyperresponsiveness. PAF has potent activity as a chemotactic agent and as an activator of eosinophils, which are prominent cells in asthmatic airways, through the activation of specific surface receptors. The interaction between PAF and eosinophils may be crucial in the pathogenesis of bronchial hyperresponsiveness in asthma. A role for PAF in asthma can now be studied using the recently developed antagonists of the PAF receptor.

PMID:: 1819715; [PubMed - indexed for MEDLINE]

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Review The contribution of platelet-activating factor to allergen-induced eosinophil infiltration and bronchial hyperresponsiveness. [Lipids. 1991]
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Page CP. Lipids. 1991 Dec; 26(12):1280-2.
Review The interaction between PAF, platelets and eosinophils in bronchial asthma. [Eur Respir J Suppl. 1989]
Review The interaction between PAF, platelets and eosinophils in bronchial asthma.
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[Involvement of platelet activating factor (PAF) in ovalbumin antigen-induced late asthmatic response and increase of airway hyperresponsiveness in a guinea pig experimental model of asthma].
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Cited by 2 PubMed Central articles

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