Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Lipidol. 2008 Feb;19(1):39-42. doi: 10.1097/MOL.0b013e3282f1c57f.

Vitamin K intake and atherosclerosis.

Author information

  • 1School of Public Health and Clinical Nutrition, University of Kuopio, Finland. arja.erkkila@uku.fi

Abstract

PURPOSE OF REVIEW:

It has been hypothesized that insufficient intake of vitamin K may increase soft-tissue calcification owing to impaired gamma-carboxylation of the vitamin K-dependent protein matrix gamma-carboxyglutamic acid. The evidence to support this putative role of vitamin K intake in atherosclerosis is reviewed.

RECENT FINDINGS:

In animal models, multiple forms of vitamin K have been shown to reverse the arterial calcification created by vitamin K antagonists. The human data, however, are less consistent. Phylloquinone, the primary dietary form, has not been associated consistently with the risk of cardiovascular diseases. High menaquinone intake may be associated with lower risk of coronary heart disease mortality, but this needs to be confirmed.

SUMMARY:

The role of vitamin K in calcification remains controversial. Although biologically plausible, results from the human studies have not consistently supported this hypothesis.

PMID:
18196985
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk