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1: Gan To Kagaku Ryoho. 2008 Jan;35(1):137-9.Click here to read Links

[A case of salvage chemotherapy with gemcitabine hydrochloride and nedaplatin for gemcitabine-refractory pancreatic cancer]

[Article in Japanese]

Matsuda M, Watanabe G, Hashimoto M.

Dept. of Surgery, Toranomon Hospital.

A 73-year-old woman with carcinoma of the pancreatic head underwent Whipple?s operation and intraoperative radiation therapy(20 Gy). After surgery, adjuvant chemotherapy with gemcitabine hydrochloride(GEM 1,000 mg every two weeks)was conducted. After 15 courses, the tumor marker CA19-9 gradually increased to 3,770 U/mL, and a supraclavicular lymph node metastasis(Virchow?s node)was detected. We selected the combination of GEM and nedaplatin(1,000 mg and 50 mg every two weeks, respectively)as salvage chemotherapy. After six courses of this nedaplatin/GEM combination, her CA19-9 level was markedly reduced to 657 U/mL and the lymph node metastasis disappeared. There were no adverse reactions. Combined nedaplatin/GEM therapy was continued for nine months(18 courses)until lung metastases occurred. This combination can be effective in some patients with GEM-refractory pancreatic cancer.

PMID: 18195544 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Gemcitabine Hydrochloride (Gemzar® )

    Your doctor has ordered the drug gemcitabine to help treat your illness. The drug is given by injection into your vein.

  • Source: AHFS Consumer Medication Information