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Arch Neurol. 2008 Jan;65(1):26-35. doi: 10.1001/archneurol.2007.10.

Modeling axonal degeneration within the anterior visual system: implications for demonstrating neuroprotection in multiple sclerosis.

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  • 1Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.


A major objective in multiple sclerosis therapeutics is to develop strategic targeting of specific injury pathways to provide neuroprotection and potentially even restoration. Here we underscore the potential utility of the anterior visual system for the purpose of modeling neuroprotection in response to novel therapies.

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