Carbohydr Res. 2008 Mar 17;343(4):651-9. Epub 2008 Jan 14.

Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (Leptospermum scoparium) honey.

Adams CJ, Boult CH, Deadman BJ, Farr JM, Grainger MN, Manley-Harris M, Snow MJ.

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Chemistry Department, University of Waikato, Private Bag 3105, Hamilton, New Zealand.

Erratum in

Carbohydr Res. 2009 Dec 14;344(18):2609.

Abstract

Using HPLC a fraction of New Zealand manuka honey has been isolated, which gives rise to the non-peroxide antibacterial activity. This fraction proved to be methylglyoxal, a highly reactive precursor in the formation of advanced glycation endproducts (AGEs). Methylglyoxal concentrations in 49 manuka and 34 non-manuka honey samples were determined using a direct detection method and compared with values obtained using standard o-phenylenediamine derivatisation. Concentrations obtained using both the methods were similar and varied from 38 to 828 mg/kg.

PMID:: 18194804; [PubMed - indexed for MEDLINE]

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Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (Leptospermum scoparium) honey.

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