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Free Radic Biol Med. 2008 Mar 15;44(6):1120-30. doi: 10.1016/j.freeradbiomed.2007.12.019. Epub 2007 Dec 23.

Photodynamic activity of platinum(IV) chloride surface-modified TiO2 irradiated with visible light.

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  • 1Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.


The visible light-induced phototoxicity of titanium dioxide modified with platinum(IV) chloride complexes, [TiO2/PtCl4], was tested. In vitro experiments with the mouse melanoma cells (S-91) have demonstrated phototoxicity of the [TiO2/PtCl4] material. Detection of efficiently generated various reactive oxygen species (.OH, O2. -, H2O2, 1O2) and also reactive chlorine species has proven the photodynamic activity of the tested material, induced by visible light (lambda>455 nm). The cellular death (recognized as a necrosis) is a result of the cell membrane peroxidation.

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