J Infect Dis. 2008 Jan 15;197(2):295-9.

Mycobacterial T cell responses in HIV-infected patients with advanced immunosuppression.

Hammond AS, McConkey SJ, Hill PC, Crozier S, Klein MR, Adegbola RA, Rowland-Jones S, Brookes RH, Whittle H, Jaye A.

Source

Bacterial and Viral Diseases Programme, Medical Research Council Laboratories, Fajara, Banjul, The Gambia, West Africa. ahammond@mrc.gm

Abstract

Antimycobacterial T cell reactivity at different stages of HIV infection was investigated. Subjects were screened with purified protein derivative (PPD), early secreted antigenic target (ESAT)-6, and culture filtrate protein (CFP)-10 antigens for interferon (IFN)-gamma-producing effector T cell responses by direct ex vivo enzyme-linked immunospot (ELISpot) assay. The proportion of responders to PPD tuberculin decreased with a reduction in CD4 T cell count, whereas the proportion of responder to ESAT-6 and CFP-10 did not. The main sources of IFN-gamma secretion were CD4 cells, and the relative responses to ESAT-6 and CFP-10 significantly increased in HIV-infected patients with decreasing CD4 cell count. This may reflect early signs of reactivation, reinfection, or a restricted, inefficient immune response to Mycobacterium tuberculosis.

PMID:: 18194089; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

HIV/AIDS - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Tuberculosis antigen-specific immune responses can be detected using enzyme-linked immunospot technology in human immunodeficiency virus (HIV)-1 patients with advanced disease. [Clin Exp Immunol. 2007]
Tuberculosis antigen-specific immune responses can be detected using enzyme-linked immunospot technology in human immunodeficiency virus (HIV)-1 patients with advanced disease.
Clark SA, Martin SL, Pozniak A, Steel A, Ward B, Dunning J, Henderson DC, Nelson M, Gazzard B, Kelleher P. Clin Exp Immunol. 2007 Nov; 150(2):238-44. Epub 2007 Aug 2.
Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells. [AIDS. 2002]
Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells.
Chapman AL, Munkanta M, Wilkinson KA, Pathan AA, Ewer K, Ayles H, Reece WH, Mwinga A, Godfrey-Faussett P, Lalvani A. AIDS. 2002 Nov 22; 16(17):2285-93.
Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons. [J Infect Dis. 2008]
Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons.
Day CL, Mkhwanazi N, Reddy S, Mncube Z, van der Stok M, Klenerman P, Walker BD. J Infect Dis. 2008 Apr 1; 197(7):990-9.
Review [Evolution of IGRA researches]. [Kekkaku. 2008]
Review [Evolution of IGRA researches].
Ariga H, Harada N. Kekkaku. 2008 Sep; 83(9):641-52.
Review The role of flow cytometry in the interferon-gamma-based diagnosis of active tuberculosis and its coinfection with HIV-1--A technically oriented review. [Cytometry B Clin Cytom. 2008]
Review The role of flow cytometry in the interferon-gamma-based diagnosis of active tuberculosis and its coinfection with HIV-1--A technically oriented review.
Janossy G, Barry SM, Breen RA, Hardy GA, Lipman M, Kern F. Cytometry B Clin Cytom. 2008; 74 Suppl 1:S141-51.

See reviews... See all...

Cited by 3 PubMed Central articles

Review HIV and tuberculosis: a deadly human syndemic. [Clin Microbiol Rev. 2011]
Review HIV and tuberculosis: a deadly human syndemic.
Kwan CK, Ernst JD. Clin Microbiol Rev. 2011 Apr; 24(2):351-76.
DR*W201/P65 tetramer visualization of epitope-specific CD4 T-cell during M. tuberculosis infection and its resting memory pool after BCG vaccination. [PLoS One. 2009]
DR*W201/P65 tetramer visualization of epitope-specific CD4 T-cell during M. tuberculosis infection and its resting memory pool after BCG vaccination.
Wei H, Wang R, Yuan Z, Chen CY, Huang D, Halliday L, Zhong W, Zeng G, Shen Y, Shen L, et al. PLoS One. 2009 Sep 4; 4(9):e6905. Epub 2009 Sep 4.
Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection. [J Infect Dis. 2008]
Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection.
Geldmacher C, Schuetz A, Ngwenyama N, Casazza JP, Sanga E, Saathoff E, Boehme C, Geis S, Maboko L, Singh M, et al. J Infect Dis. 2008 Dec 1; 198(11):1590-8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Mycobacterial T cell responses in HIV-infected patients with advanced immunosupp...
Mycobacterial T cell responses in HIV-infected patients with advanced immunosuppression.
J Infect Dis. 2008 Jan 15 ;197(2):295-9.

PubMed
[The synthesis of the epidemiology and treatment of malaria of the pregnant woma...
[The synthesis of the epidemiology and treatment of malaria of the pregnant woman and the infant in subsaharan Africa].
Bull Soc Pathol Exot. 1991 ;84(5 Pt 5):492-6.

PubMed
Evolution and selection in yeast promoters: analyzing the combined effect of div...
Evolution and selection in yeast promoters: analyzing the combined effect of diverse transcription factor binding sites.
PLoS Comput Biol. 2008 Jan ;4(1):e7.

PubMed
Misfolding of the cystic fibrosis transmembrane conductance regulator and diseas...
Misfolding of the cystic fibrosis transmembrane conductance regulator and disease.
Biochemistry. 2008 Feb 12 ;47(6):1465-73. Epub 2008 Jan 15 .

PubMed
Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthes...
Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.
Acc Chem Res. 2008 Jan ;41(1):11-20.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Mycobacterial T cell responses in HIV-infected patients with advanced immunosuppression.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information