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    Nat Genet. 2008 Feb;40(2):149-51. Epub 2008 Jan 13.

    Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.

    Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR, Gómez Pérez FJ, Frazer KA, Elliott P, Scott J, Milos PM, Cox DR, Thompson JF.

    Source

    National Heart and Lung Institute, Imperial College London, UK. j.scott@imperial.ac.uk

    Abstract

    We tested over 267,000 SNPs in 1,005 Northern Europeans and 248,000 in 1,006 Indian Asians for association with triglycerides and HDL cholesterol, with replication in 10,536 subjects. We found association of a nonsynonymous SNP (rs3812316, G771C, Gln241His) in MLXIPL with plasma triglyceride levels (combined P = 1.4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'.

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    PMID:
    18193046
    [PubMed - indexed for MEDLINE]

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