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1: Biochem Pharmacol. 2008 Mar 15;75(6):1411-5. Epub 2007 Dec 4.Click here to read Click here to read Links

Lobeline effects on tonic and methamphetamine-induced dopamine release.

Wilhelm CJ, Johnson RA, Eshleman AJ, Janowsky A.

Research Service, Veterans Affairs Medical Center, Portland, OR 97239, USA.

The mechanisms of interaction between lobeline and the dopamine transporter (DAT) or the vesicular monoamine transporter (VMAT-2) are not clear. The goal of this study was to elucidate the effects of lobeline on these transporters in a cell system co-expressing the DAT and VMAT-2. Lobeline caused release of [(3)H]dopamine to a similar extent as reserpine (VMAT-2 inhibitor), but was less efficacious than methamphetamine or dopamine. Additionally, lobeline decreased the [(3)H]dopamine-releasing effects of methamphetamine, unlike reserpine which increased release by methamphetamine. These results suggest that lobeline has unique properties at the DAT and VMAT-2 which may make it useful as a pharmacotherapeutic to treat methamphetamine abuse.

PMID: 18191815 [PubMed - indexed for MEDLINE]

PMCID: PMC2435375

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