Trends Biotechnol. 2008 Feb;26(2):77-81. Epub 2008 Jan 11.

Potential for metabolic engineering of resveratrol biosynthesis.

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Donald Danforth Plant Science Center, 975 North Warson Road, Saint Louis, MO 63132, USA.

Abstract

Resveratrol, an interesting plant phenolic compound, is found in red wine but is not widely distributed in other common food sources. Health benefits of resveratrol include prevention of cardiovascular diseases and cancers, and--as discovered more recently--promotion of longevity in several animal systems. The pathway and enzymes for resveratrol biosynthesis are well characterized. Furthermore, metabolic engineering of this compound has been achieved in plants, microbes and animals. This review attempts to summarize current understanding of resveratrol pathway-engineering in various systems, to outline the challenges in commercial applications and to identify future opportunities for resveratrol bioengineering.

PMID:: 18191264; [PubMed - indexed for MEDLINE]

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Potential for metabolic engineering of resveratrol biosynthesis.

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