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Fortschr Neurol Psychiatr. 2008 Jan;76(1):21-7. doi: 10.1055/s-2007-993032.

[Neuromyelitis optica: a separate disease entity associated with aquaporin-4-antibodies].

[Article in German]

Author information

  • 1Klinik und Poliklinik für Neurologie, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale. Berit.Jordan@medizin.uni-halle.de


Neuromyelitis optica (NMO; Devic's Syndrome) is an idiopathic, often relapsing, severe inflammatory disorder preferentially affecting optic nerves and spinal cord. The distinction of NMO from multiple sclerosis (MS) as a separate disease entity has been controversally discussed for a long time. Though both diseases show demyelinisation, they differ in typical clinical, imaging and immunopathological findings. The recent identification of serum aquaporin (AQP)-4 antibody clearly separates NMO from MS. In addition, the identification of AQP-4 antibodies supports peripheral humoral autoimmune pathogenesis in NMO and permits early initiation of effective therapy for prevention of attack-related disability.

[PubMed - indexed for MEDLINE]
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