Eur Biophys J. 2008 Jul;37(6):721-8. Epub 2008 Jan 9.

Mechanisms of protein folding.

Ivarsson Y, Travaglini-Allocatelli C, Brunori M, Gianni S.

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Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università di Roma La Sapienza, Piazzale A. Moro 5, 00185, Rome, Italy.

Abstract

Understanding the mechanism by which a polypeptide chain folds into its native structure is a central problem of modern biophysics. The collaborative efforts of experimental and theoretical studies recently raised the tantalizing possibility to define a unifying mechanism for protein folding. In this review we summarize some of these intriguing advances and analyze them together with a discussion on the new findings concerning the so-called downhill folding.

PMID:: 18185928; [PubMed - indexed for MEDLINE]

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