Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuroreport. 2008 Jan 22;19(2):197-201. doi: 10.1097/WNR.0b013e3282f454af.

Putative biomarker of working memory systems development during childhood and adolescence.

Author information

  • 1Cognitive Neuroscience Laboratory, Flinders University, Australia.

Erratum in

  • Neuroreport. 2005;19(6):701.

Abstract

The study aimed to identify brain functional indicators of working memory systems development between 6 and 18 years. Event-related potentials (ERPs) were recorded from 251 normally developing children to stimuli requiring the updating of working memory. Cluster analysis of event-related potential componentry divided the sample into three clusters (mean ages 9, 12 and 16 years), with ascending cluster membership independently associated with improved task performance. The clusters correspond to periods of grey matter loss and white matter increase observed in developing children, supporting the view that the clusters delineate three key qualitative stages in advancing cognitive capability during the maturation of higher brain systems function. This outcome identifies a biomarker with the potential for assessing abnormalities in the rate of brain development.

PMID:
18185108
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk