Pharmacol Ther. 1991 Nov;52(2):149-57.

Transmembrane signalling by interferon-alpha.

Source

Department of Pathology, University of Tennessee Medical Center, Memphis 38163.

Abstract

Human leukocyte interferon (IFN-alpha) binds to discrete cell surface receptors on target cells, and thereby alters gene expression. Transmembrane signaling by IFN-alpha involves the production of DAG without an increased intracellular free calcium concentration, and the subsequent activation of calcium-independent isoforms of PKC (beta and epsilon). Selective PKC inhibitors (H-7 and staurosporine) can block the ability of IFN-alpha to activate the transcription of a distinct set of genes, called the IFN-stimulated genes (ISG), and to protect cells against viral infection. IFN-alpha also induces the rapid changes in protein phosphorylation, which may include latent transcription factors for ISGs.

PMID:: 1818333; [PubMed - indexed for MEDLINE]

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MeSH Terms

Substances

Interferon-alpha

Grant Support

GM36716/GM/NIGMS NIH HHS/United States

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Cited by 1 PubMed Central article

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