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Trends Microbiol. 2008 Feb;16(2):65-72. doi: 10.1016/j.tim.2007.11.004. Epub 2008 Jan 7.

P(II) signal transducers: novel functional and structural insights.

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  • 1Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.


The P(II) signal transduction proteins have key functions in coordinating the regulation of central metabolic processes. Signals from the carbon, nitrogen and energy status of the cells are converted into different conformational (and modification) states of the P(II) proteins. Depending on these states, the P(II) proteins interact with various target proteins, most of which perform or regulate crucial reactions in nitrogen assimilatory pathways. This review presents recent progress in the elucidation of novel P(II) functions and in gaining novel structural insights into how the signals convert the P(II) states and how the activity of targets is affected by P(II) interaction.

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