Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Theor Biol Med Model. 2008 Jan 8;5:1. doi: 10.1186/1742-4682-5-1.

The Peter Pan paradigm.

Author information

  • 1The Brady Laboratory, Section of Neonatology, Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794, USA. jcraig.cohen@stonybrook.edu

Abstract

Genetic and environmental agents that disrupt organogenesis are numerous and well described. Less well established, however, is the role of delay in the developmental processes that yield functionally immature tissues at birth. Evidence is mounting that organs do not continue to develop postnatally in the context of these organogenesis insults, condemning the patient to utilize under-developed tissues for adult processes. These poorly differentiated organs may appear histologically normal at birth but with age may deteriorate revealing progressive or adult-onset pathology. The genetic and molecular underpinning of the proposed paradigm reveals the need for a comprehensive systems biology approach to evaluate the role of maternal-fetal environment on organogenesis."You may delay, but time will not" Benjamin Franklin, USA Founding Father.

PMID:
18182112
[PubMed - indexed for MEDLINE]
PMCID:
PMC2249573
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk