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J Protozool. 1991 Nov-Dec;38(6):42S-43S.

Hyperimmune hens as a novel source of anti-Cryptosporidium antibodies suitable for passive immune transfer.

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  • 1Department of Veterinary Science, University of Arizona, Tucson 85721.

Abstract

Leghorn hens were subcutaneously immunized with 25 micrograms of Cryptosporidium parvum oocyst emulsified in Freund's complete adjuvant. A booster dose was injected 5 weeks later. Anti-Cryptosporidium activities of yolks and sera measured by an enzyme-linked immunosorbent assay (ELISA), demonstrated high levels in both sera and egg yolks which persisted for at least 17 wk. Preparations from yolks with high, medium and low anti-Cryptosporidium ELISA activities were used in a neonatal mouse model to assess their biological activities. A significant parasite reduction (P less than or equal to 0.001) was found between the high and all other groups. Hyperimmune eggs could be used as a source for passive immunity in cryptosporidiosis.

PMID:
1818193
[PubMed - indexed for MEDLINE]
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