Clin Infect Dis. 2008 Feb 1;46(3):e28-30.

Tenofovir-based rescue therapy for advanced liver disease in 6 patients coinfected with HIV and hepatitis B virus and receiving lamivudine.

Gutiérrez S, Guillemi S, Jahnke N, Montessori V, Harrigan PR, Montaner JS.

Source

BC Centre for Excellence in HIV/AIDS, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.

Abstract

We summarize the clinical history and laboratory results following the introduction of tenofovir among 6 patients coinfected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) who presented with severe liver disease while receiving lamivudine-based highly active antiretroviral therapy. In all cases, the introduction of tenofovir led to a sustained undetectable HBV and HIV loads, with marked clinical and laboratory improvement in liver function. We provide supporting evidence for the role of tenofovir in the management of advanced HBV infection in HIV-positive patients after the development of lamivudine resistance.

PMID:: 18181733; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

LAMIVUDINE - HSDB

Supplemental Content

Related citations

Combination of tenofovir and lamivudine versus tenofovir after lamivudine failure for therapy of hepatitis B in HIV-coinfection. [AIDS. 2006]
Combination of tenofovir and lamivudine versus tenofovir after lamivudine failure for therapy of hepatitis B in HIV-coinfection.
Schmutz G, Nelson M, Lutz T, Sheldon J, Bruno R, von Boemmel F, Hoffmann C, Rockstroh J, Stoehr A, Wolf E, et al. AIDS. 2006 Oct 3; 20(15):1951-4.
Impact of tenofovir-containing antiretroviral therapy on chronic hepatitis B in a cohort co-infected with human immunodeficiency virus. [J Antimicrob Chemother. 2005]
Impact of tenofovir-containing antiretroviral therapy on chronic hepatitis B in a cohort co-infected with human immunodeficiency virus.
Stephan C, Berger A, Carlebach A, Lutz T, Bickel M, Klauke S, Staszewski S, Stuermer M. J Antimicrob Chemother. 2005 Dec; 56(6):1087-93. Epub 2005 Nov 3.
Efficacy of tenofovir disoproxil fumarate in antiretroviral therapy-naive and -experienced patients coinfected with HIV-1 and hepatitis B virus. [J Infect Dis. 2004]
Efficacy of tenofovir disoproxil fumarate in antiretroviral therapy-naive and -experienced patients coinfected with HIV-1 and hepatitis B virus.
Dore GJ, Cooper DA, Pozniak AL, DeJesus E, Zhong L, Miller MD, Lu B, Cheng AK, 903 Study Team, 907 Study Team. J Infect Dis. 2004 Apr 1; 189(7):1185-92. Epub 2004 Mar 12.
Review [Hepatitis B in patients with HIV infection]. [Enferm Infecc Microbiol Clin. 2008]
Review [Hepatitis B in patients with HIV infection].
Barreiro P, Martín-Carbonero L, García-Samaniego J. Enferm Infecc Microbiol Clin. 2008 May; 26 Suppl 7:71-9.
Review Antiretroviral therapy for hepatitis B virus-HIV-coinfected patients: promises and pitfalls. [Clin Infect Dis. 2006]
Review Antiretroviral therapy for hepatitis B virus-HIV-coinfected patients: promises and pitfalls.
Levy V, Grant RM. Clin Infect Dis. 2006 Oct 1; 43(7):904-10. Epub 2006 Aug 23.

See reviews... See all...

Cited by 3 PubMed Central articles

Antiviral treatment of chronic hepatitis B virus (HBV) infections. [Viruses. 2010]
Antiviral treatment of chronic hepatitis B virus (HBV) infections.
De Clercq E, Férir G, Kaptein S, Neyts J. Viruses. 2010 Jun; 2(6):1279-305. Epub 2010 May 31.
New approaches in the management of chronic hepatitis B: role of tenofovir. [Infect Drug Resist. 2009]
New approaches in the management of chronic hepatitis B: role of tenofovir.
Reijnders JG, LA Janssen H. Infect Drug Resist. 2009; 2:13-26. Epub 2009 Apr 24.
Tenofovir and its potential in the treatment of hepatitis B virus. [Ther Clin Risk Manag. 2009]
Tenofovir and its potential in the treatment of hepatitis B virus.
Reynaud L, Carleo MA, Talamo M, Borgia G. Ther Clin Risk Manag. 2009 Feb; 5(1):177-85. Epub 2009 Mar 26.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Tenofovir-based rescue therapy for advanced liver disease in 6 patients coinfect...
Tenofovir-based rescue therapy for advanced liver disease in 6 patients coinfected with HIV and hepatitis B virus and receiving lamivudine.
Clin Infect Dis. 2008 Feb 1 ;46(3):e28-30.

PubMed
Effective treatment of experimental glioblastoma by HSV vector-mediated TNF alph...
Effective treatment of experimental glioblastoma by HSV vector-mediated TNF alpha and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration.
Mol Ther. 2000 Aug ;2(2):114-20.

PubMed
The development and impact of 454 sequencing.
The development and impact of 454 sequencing.
Nat Biotechnol. 2008 Oct ;26(10):1117-24.

PubMed
Outcome correlates of parent-child bedsharing: an eighteen-year longitudinal stu...
Outcome correlates of parent-child bedsharing: an eighteen-year longitudinal study.
J Dev Behav Pediatr. 2002 Aug ;23(4):244-53.

PubMed
The rate of uptake of nitrous oxide in man.
The rate of uptake of nitrous oxide in man.
J Clin Invest. 1954 Sep ;33(9):1183-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Tenofovir-based rescue therapy for advanced liver disease in 6 patients coinfected with HIV and hepatitis B virus and receiving lamivudine.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information