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J Chromatogr. 1991 Dec 6;572(1-2):195-202.

Determination of zopiclone enantiomers in plasma by liquid chromatography using a chiral cellulose carbamate column.

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  • 1Hôpital Pitié Salpétrière, Service Pharmacie, Paris, France.


The enantiomers of zopiclone were determined in human plasma using a sequential achiral-chiral liquid chromatographic method. Zopiclone was separated from the biological matrix and quantified on an achiral silica column. The limit of detection was 5 ng/ml. The eluent fraction containing zopiclone was collected, evaporated, reconstituted with the mobile phase and injected onto a chiral cellulose carbamate column where the enantiomeric ratio was calculated. This validated method, applied to a pilot study, suggests that pharmacokinetics of zopiclone is stereoselective.

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