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J Cell Biol. 2008 Jan 14;180(1):23-9. doi: 10.1083/jcb.200709133. Epub 2008 Jan 7.

Intraflagellar transport motors in cilia: moving along the cell's antenna.

Author information

  • Department of Molecular and Cell Biology, University of California, Davis, Davis, CA 95616, USA. jmscholey@ucdavis.edu

Abstract

Intraflagellar transport (IFT), the motor-dependent movement of IFT particles along the axoneme, is critical for the assembly, maintenance, and function of motile and sensory cilia, and, consequently, this process underlies ciliary motility, cilium-based signaling, and ciliopathies. Here, I present my perspective on IFT as a model system for studying motor-driven cargo transport. I review evidence that kinesin-2 motors physically transport IFT particles as cargo and hypothesize that several accessory kinesins confer cilia-specific functions by augmenting the action of the two core IFT motors, kinesin-2 and dynein 1b, which assemble the cilium foundation.

PMID:
18180368
[PubMed - indexed for MEDLINE]
PMCID:
PMC2213603
Free PMC Article
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