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Seizure. 2008 Mar;17(2):192-8. doi: 10.1016/j.seizure.2007.11.027. Epub 2008 Jan 3.

Serum concentration/dose ratio of levetiracetam before, during and after pregnancy.

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  • 1Department of Clinical Pharmacology, St. Olavs Hospital, Olav Kyrres gate 17, N-7006 Trondheim, Norway. andreas.westin@legemidler.no

Abstract

PURPOSE:

To investigate changes in levetiracetam (LEV) serum concentration/dose ratio (C/D-ratio) in relation to pregnancy.

METHODS:

Altogether 21 consecutive pregnancies in 20 women with epilepsy receiving LEV during gestation were studied retrospectively. The main target variable was the C/D-ratio before and during pregnancy, and in the post partum period. Secondary target variables were changes in LEV dose, concomitant use of other antiepileptic drugs and seizure frequency. Student's paired t-test and two-sample t-test for independent samples were used to test for statistically significant changes in C/D-ratio means.

RESULTS:

Mean C/D-ratio in the third trimester was 50% of the mean C/D-ratio at baseline (p<0.001, n=11). Baseline levels were reached within the first weeks after pregnancy. The interindividual variability was pronounced.

CONCLUSIONS:

Serum concentrations of LEV declined significantly in the third trimester of pregnancy and increased rapidly after delivery.

PMID:
18180176
[PubMed - indexed for MEDLINE]
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