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Vaccine. 2008 Jun 6;26(24):2997-3001. doi: 10.1016/j.vaccine.2007.11.060. Epub 2007 Dec 17.

The emerging role of innate immunity in protection against HIV-1 infection.

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  • 1Kings College London at Guy's Hospital, London SE1 9RT, England, United Kingdom. thomas.lehner@kcl.ac.uk

Abstract

Preventive immunization against HIV-1 infection requires a rapid immune response that does not rely exclusively on B or T cell memory. Innate immunity may fulfill this function as it may be activated directly at the time of HIV-1 transmission, inhibit early HIV-1 replication, stimulate adaptive immunity and enable specific antibodies followed by CD8(+) T cells to deal with the virus effectively. The three components of innate immunity - cellular, extracellular and intracellular - are presented, with an example given for each of these components; gammadelta T cells, CC chemokines and APOBEC3G. This brief account is presented to highlight the immuno-virological concept of coordinating activated innate immunity with adaptive antibody and T cell responses in preventive vaccination against HIV-1 infection.

PMID:
18180080
[PubMed - indexed for MEDLINE]
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