Biochem Biophys Res Commun. 2008 Mar 14;367(3):560-5. Epub 2008 Jan 7.

Adiponectin binds C1q and activates the classical pathway of complement.

Peake PW, Shen Y, Walther A, Charlesworth JA.

Source

Division of Medicine, Prince of Wales Hospital, High Street, Randwick, Sydney, NSW 2031, Australia.

Abstract

The adipose-specific protein adiponectin binds to a number of target molecules, including damaged endothelium and the surface of apoptotic cells. However, the significance of this binding remains unclear. This study demonstrates the binding of purified C1q to recombinant adiponectin under physiological conditions, and the dependence of this upon Ca(++) and Mg(++). Binding was enhanced by metaperiodate-mediated destruction of glucosylgalactosyl sugars on adiponectin. Adiponectin was bound by the globular domain of the A chain of collagenase-digested C1q, and C1q binding induced deposition of C4 and C3 through activation of the classical complement pathway. After Western blotting, affinity-purified adiponectin from human serum bound C1q, whereas adiponectin in whole serum did not, unless pre-treated with metaperiodate. These results suggest adiponectin is member of the pattern-recognition family of defence collagens, able to bind target molecules and activate complement. It may therefore play an important role in innate immunity and autoimmune phenomena.

PMID:: 18179772; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Blood platelets activate the classical pathway of human complement. [J Thromb Haemost. 2006]
Blood platelets activate the classical pathway of human complement.
Peerschke EI, Yin W, Grigg SE, Ghebrehiwet B. J Thromb Haemost. 2006 Sep; 4(9):2035-42.
Direct binding of C1q to apoptotic cells and cell blebs induces complement activation. [Eur J Immunol. 2002]
Direct binding of C1q to apoptotic cells and cell blebs induces complement activation.
Nauta AJ, Trouw LA, Daha MR, Tijsma O, Nieuwland R, Schwaeble WJ, Gingras AR, Mantovani A, Hack EC, Roos A. Eur J Immunol. 2002 Jun; 32(6):1726-36.
Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation. [Biochemistry. 2006]
Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation.
Inforzato A, Peri G, Doni A, Garlanda C, Mantovani A, Bastone A, Carpentieri A, Amoresano A, Pucci P, Roos A, et al. Biochemistry. 2006 Sep 26; 45(38):11540-51.
Review Interaction of C1q and mannan-binding lectin with viruses. [Immunobiology. 2002]
Review Interaction of C1q and mannan-binding lectin with viruses.
Thielens NM, Tacnet-Delorme P, Arlaud GJ. Immunobiology. 2002 Sep; 205(4-5):563-74.
Review Methods to detect and quantitate complement activation. [Springer Semin Immunopathol. 1...]
Review Methods to detect and quantitate complement activation.
Cooper NR, Nemerow GR, Mayes JT. Springer Semin Immunopathol. 1983; 6(2-3):195-212.

See reviews... See all...

Cited by 2 PubMed Central articles

Change in circulating adiponectin in advanced old age: determinants and impact on physical function and mortality. The Cardiovascular Health Study All Stars Study. [J Gerontol A Biol Sci Med Sci....]
Change in circulating adiponectin in advanced old age: determinants and impact on physical function and mortality. The Cardiovascular Health Study All Stars Study.
Kizer JR, Arnold AM, Strotmeyer ES, Ives DG, Cushman M, Ding J, Kritchevsky SB, Chaves PH, Hirsch CH, Newman AB. J Gerontol A Biol Sci Med Sci. 2010 Nov; 65(11):1208-14. Epub 2010 Jul 8.
Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study. [Diabetes Care. 2009]
Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study.
Jain SH, Massaro JM, Hoffmann U, Rosito GA, Vasan RS, Raji A, O'Donnell CJ, Meigs JB, Fox CS. Diabetes Care. 2009 May; 32(5):903-8. Epub 2009 Feb 17.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Adiponectin binds C1q and activates the classical pathway of complement.
Adiponectin binds C1q and activates the classical pathway of complement.
Biochem Biophys Res Commun. 2008 Mar 14 ;367(3):560-5. Epub 2008 Jan 7 .

PubMed
Differential effects of all-trans retinoic acid on the growth of human keratinoc...
Differential effects of all-trans retinoic acid on the growth of human keratinocytes and mouth carcinoma epidermoid cultures. Involvement of GRIM-19 and complex I of the respiratory chain.
Int J Immunopathol Pharmacol. 2007 Oct-Dec ;20(4):719-29.

PubMed
The effectiveness of psychodynamic-interpersonal therapy (PIT) in routine clinic...
The effectiveness of psychodynamic-interpersonal therapy (PIT) in routine clinical practice: a benchmarking comparison.
Psychol Psychother. 2008 Jun ;81(Pt 2):157-75. Epub 2008 Jan 4 .

PubMed
Effects of atomoxetine on attention-deficit/hyperactivity disorder in clinical p...
Effects of atomoxetine on attention-deficit/hyperactivity disorder in clinical pediatric treatment settings: a naturalistic study.
Curr Med Res Opin. 2008 Feb ;24(2):449-60.

PubMed
A systematic review of school-based sexual health interventions to prevent STI/H...
A systematic review of school-based sexual health interventions to prevent STI/HIV in sub-Saharan Africa.
BMC Public Health. 2008 Jan 7 ;8:4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: