Eukaryot Cell. 2008 Mar;7(3):537-40. Epub 2008 Jan 4.

Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation.

Gissot M, Choi SW, Thompson RF, Greally JM, Kim K.

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Albert Einstein College of Medicine, Ullmann 1225, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

Abstract

Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.

PMID:: 18178772; [PubMed - indexed for MEDLINE]
PMCID: PMC2268521

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