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    Cell Metab. 2008 Jan;7(1):21-32.

    Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.

    Teleman AA, Hietakangas V, Sayadian AC, Cohen SM.

    Source

    EMBL, Meyerhofstrasse 1, Heidelberg, Germany.

    Abstract

    Animals use the insulin/TOR signaling pathway to mediate their response to fluctuations in nutrient availability. Energy and amino acids are monitored at the single-cell level via the TOR branch of the pathway and systemically via insulin signaling to regulate cellular growth and metabolism. Using a combination of genetics, expression profiling, and chromatin immunoprecipitation, we examine nutritional control of gene expression and identify the transcription factor Myc as an important mediator of TOR-dependent regulation of ribosome biogenesis. We also identify myc as a direct target of FOXO and provide genetic evidence that Myc has a key role in mediating the effects of TOR and FOXO on growth and metabolism. FOXO and TOR also converge to regulate protein synthesis, acting via 4E-BP and Lk6, regulators of the translation factor eIF4E. This study uncovers a network of convergent regulation of protein biosynthesis by the FOXO and TOR branches of the nutrient-sensing pathway.

    PMID:
    18177722
    [PubMed - indexed for MEDLINE]

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