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PLoS Med. 2008 Jan 3;5(1):e4. doi: 10.1371/journal.pmed.0050004.

In the era of systematic reviews, does the size of an individual trial still matter.

Author information

  • 1Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada. guyatt@mcmaster.ca

Abstract

BACKGROUND TO THE DEBATE:

Systematic reviews that combine high-quality evidence from several trials are now widely considered to be at the top of the hierarchy of clinical evidence. Given the primacy of systematic reviews-and the fact that individual clinical trials rarely provide definitive answers to a clinical research question-some commentators question whether the sample size calculation for an individual trial still matters. Others point out that small trials can still be potentially misleading.

PMID:
18177203
[PubMed - indexed for MEDLINE]
PMCID:
PMC2174963
Free PMC Article
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