Am J Phys Med Rehabil. 2008 Mar;87(3):229-31.

Increased arousal in a patient with anoxic brain injury after administration of zolpidem.

Source

Division of Physical Medicine and Rehabilitation, Department of Orthopedic Surgery, Stanford University, California, USA.

Abstract

A 35-yr-old man sustained an anoxic brain injury resulting from cardiac arrest, with subsequent extreme lethargy and lack of response to stimuli. The patient's lethargy was unresponsive to trials of several medications in attempts to increase arousal. Administration of twice-daily zolpidem 8 mos after injury resulted in a dramatic increase in the level of alertness, including improved speech and gait. When the patient was not able to receive zolpidem for a brief period, the patient's lethargy returned, and he became bedbound until the medication was resumed.

PMID:: 18174850; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Coma - MedlinePlus Health Information

Molecular Biology Databases

ZOLPIDEM TARTRATE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Drug induced arousal from the permanent vegetative state. [NeuroRehabilitation. 2006]
Drug induced arousal from the permanent vegetative state.
Clauss R, Nel W. NeuroRehabilitation. 2006; 21(1):23-8.
Transient reversal of anoxic brain injury-related minimally conscious state after zolpidem administration: a case report. [Arch Phys Med Rehabil. 2008]
Transient reversal of anoxic brain injury-related minimally conscious state after zolpidem administration: a case report.
Shames JL, Ring H. Arch Phys Med Rehabil. 2008 Feb; 89(2):386-8.
Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial. [Am J Phys Med Rehabil. 2009]
Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial.
Whyte J, Myers R. Am J Phys Med Rehabil. 2009 May; 88(5):410-8.
Review Zolpidem therapy for movement disorders. [Recent Pat CNS Drug Discov. 2008]
Review Zolpidem therapy for movement disorders.
Abe K. Recent Pat CNS Drug Discov. 2008 Jan; 3(1):55-60.
Review Amantadine enhancement of arousal and cognition after traumatic brain injury. [Ann Pharmacother. 2008]
Review Amantadine enhancement of arousal and cognition after traumatic brain injury.
Sawyer E, Mauro LS, Ohlinger MJ. Ann Pharmacother. 2008 Feb; 42(2):247-52. Epub 2008 Jan 22.

See reviews... See all...

Cited by 2 PubMed Central articles

Review Zolpidem-induced sleepwalking, sleep related eating disorder, and sleep-driving: fluorine-18-flourodeoxyglucose positron emission tomography analysis, and a literature review of other unexpected clinical effects of zolpidem. [J Clin Sleep Med. 2009]
Review Zolpidem-induced sleepwalking, sleep related eating disorder, and sleep-driving: fluorine-18-flourodeoxyglucose positron emission tomography analysis, and a literature review of other unexpected clinical effects of zolpidem.
Hoque R, Chesson AL Jr. J Clin Sleep Med. 2009 Oct 15; 5(5):471-6.
Review Recovery of consciousness after brain injury: a mesocircuit hypothesis. [Trends Neurosci. 2010]
Review Recovery of consciousness after brain injury: a mesocircuit hypothesis.
Schiff ND. Trends Neurosci. 2010 Jan; 33(1):1-9. Epub 2009 Dec 1.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Increased arousal in a patient with anoxic brain injury after administration of ...
Increased arousal in a patient with anoxic brain injury after administration of zolpidem.
Am J Phys Med Rehabil. 2008 Mar ;87(3):229-31.

PubMed
Suicide attempt characteristics, diagnoses, and future attempts: comparing multi...
Suicide attempt characteristics, diagnoses, and future attempts: comparing multiple attempters to single attempters and ideators.
J Am Acad Child Adolesc Psychiatry. 2008 Jan ;47(1):32-40.

PubMed
Effect of the full moon on a sample of developmentally delayed, institutionalize...
Effect of the full moon on a sample of developmentally delayed, institutionalized women.
Percept Mot Skills. 1991 Jun ;72(3 Pt 2):1375-80.

PubMed
Tacrolimus in dermatology-pharmacokinetics, mechanism of action, drug interactio...
Tacrolimus in dermatology-pharmacokinetics, mechanism of action, drug interactions, dosages, and side effects: part I.
Skinmed. 2008 Jan-Feb ;7(1):27-30.

PubMed
Childhood diet, overweight, and CVD risk factors: the Healthy Start project.
Childhood diet, overweight, and CVD risk factors: the Healthy Start project.
Prev Cardiol. 2008 Winter ;11(1):11-20.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: