Int J Tuberc Lung Dis. 2008 Jan;12(1):105-7.

Drug susceptibility profiling of tuberculous meningitis.

Nagarathna S, Rafi W, Veenakumari HB, Mani R, Satishchandra P, Chandramuki A.

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Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India. nagarathnachandrashekar@gmail.com

Abstract

Drug-resistant tuberculosis is an increasing problem worldwide. There are few reports of drug susceptibility patterns of Mycobacterium tuberculosis isolated from cases of tuberculous meningitis. A 5-year retrospective study aimed at analysing the drug susceptibility profile of M. tuberculosis isolated from tuberculous meningitis cases was conducted. A total of 366 isolates were analysed. Among these, 301 (82.2%) were sensitive to all the four primary drugs tested, while 65 (17.8%) showed resistance. There were 46 (12.5%) isolates resistant to isoniazid (INH), while 9 (2.4%) demonstrated multidrug resistance. These data suggest that multidrug resistance in tuberculous meningitis is not yet a serious problem. However, a periodic review is required to ascertain the global incidence of drug-resistant tuberculous meningitis.

PMID:: 18173886; [PubMed - indexed for MEDLINE]

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